BIND Therapeutics & BIND RUS
Pharmaceuticals Based on the BIND Therapeutics’ Accurins™ Nanoplatform
Shareholders in Portfolio Company
Investment Started: 2011
Development and commercialization of a new class of highly selective targeted therapeutics based on BIND Therapeutics’s Accurins™ nanoplatform
BIND Therapeutics develops targeted therapeutics, called Accurins™, that selectively accumulate at the site of disease to dramatically enhance effectiveness for treating cancer and other diseases. BIND’s lead candidate, BIND-014, is in human clinical trials as a targeted therapy for cancer treatment. BIND’s development pipeline also includes other cancer treatments and drugs for
BIND’s patented Accurins™ platform together with Selecta Biosciences’s tSVP™ vaccine platform originated in laboratories at Harvard Medical School under the direction of Professor Omid Farokhzad, MD and in laboratories at MIT under the direction of Professor Robert S. Langer. Professor Langer’s lab is renowned for research work on targeted drug delivery technology. Robert Langer is a recipient of the National Medal of Science, the most prestigious honor for scientists bestowed by the United States, and an author of approximately 850 patents issued or pending worldwide.
Area of application
- Treatment of oncological,
cardio-vascular, inflammatory and other diseases
- Healthcare providers and their patients
- Platform for rapid development of innovative pharmaceuticals
- Highly effective drugs
- Lower toxicity
- Fewer side effects
19 November 2015
24 September 2015
02 June 2014
06 February 2014BIND (RUS) Launches Its New Research & Development Center in Moscow
Portfolio Company’s News
27 November 2013
22 April 2013
10 April 2013
03 April 2013
02 April 2013Reflecting its Growth, BIND Biosciences Changes Name to BIND Therapeutics
Portfolio Company’s News
10 January 2013BIND and Amgen Sign Development & Commercialization Agreement for Kinase Inhibitor Nanomedicine
Portfolio Company’s News
10 August 2012Russia Ready to Build a ‘Permanent’ Biopharma Market
21 February 2012Russia’s RUSNANO Pours Rubles into Tech Start-Ups Abroad
11 January 2012Russian Fund Steps up Investments in Innovative Biotechs
27 October 2011
Technologies and Products
BIND is discovering and developing AccurinsTM, proprietary new best-in-class therapeutics with superior target selectivity, and an improved therapeutic index.
Leveraging our proprietary Medicinal Nanoengineering® platform, we develop Accurins that outperform conventional systemic drugs by selectively accumulating in diseased tissues and cells. The result is higher drug concentrations at the site of action with minimal off-target exposure, leading to markedly better efficacy and safety.
BIND's targeted Accurins consist of the following components that facilitate selective targeting of diseased cells and tissues:
- Targeting ligand: The ability to attach targeting ligands to nanoparticles is a unique and valuable aspect of our technology. We develop targeting ligands that recognize specific disease-associated cell-surface proteins or receptors, enabling Accurins to preferentially accumulate at their intended site of action.
- Stealth and protective layer: Engineered using proprietary methods for precisely controlling the Accurin surface characteristics, the stealth and protective layer shields targeted nanoparticles from immune surveillance, while providing attachment sites for the targeting ligand through proprietary linking chemistries.
- Therapeutic payload (API): We can incorporate a broad range of active pharmaceutical ingredients into our targeted nanoparticles, including small molecules, peptides, proteins, and nucleic acids, such as siRNA.
- Controlled-release polymers: The API payload is encapsulated in a matrix of clinically validated, biodegradable, and biocompatible polymers that mediate the release of the payload at the site of disease at an optimal rate.
Medicinal Nanoengineering® Platform
We create Accurins using a proprietary Medicinal Nanoengineering® platform that enables predictable, rapid design and optimization of targeted therapeutics with precisely controlled pharmacokinetic and biodistribution properties. We apply this platform to develop highly selective targeted therapeutics with unprecedented efficacy and tolerability.
The Medicinal Nanoengineering platform has demonstrated proof of concept across a broad range of drug classes and therapeutic areas. Preclinical studies validate the ability of our technology to improve the therapeutic index of cytotoxic agents, molecularly targeted anticancer drugs, and therapies for treating inflammation and pain.
The Medicinal Nanoengineering platform uses a combinatorial approach to design and engineer nanoparticles with optimal targeting and drug-release properties, and subsequent production of materials for drug development and commercialization:
- We design combinatorial libraries of targeted nanoparticles with precise and systematically varied biophysicochemical properties such as particle size, surface properties, ligand density, drug load, and drug release profile, using a unique self-assembly nanoparticle fabrication process to optimize each product-for example, to balance circulation time with effective targeting and binding for a particular cell or tissue target.
- We engineer product candidates with optimal performance properties using an iterative process that includes in vitro drug release and cell binding as along with in vivo PK, tolerability, biodistribution, targeting, and efficacy studies.
- We manufacture candidate Accurins from gram-scale laboratory experiments through kilogram-scale GMP clinical batches using robust, reproducible, and scalable processes.
Our technology incorporates a therapeutic payload into a nanoparticle and achieves targeting through a dual mechanism:
- Passive/Biophysical Targeting: We engineer biophysical properties of the nanoparticles to avoid immune surveillance and fit through gaps in blood vessels surrounding tumors and other disease sites
- Active/Ligand-Directed, Receptor-Mediated Binding: We attach a targeting ligand on the surface of the nanoparticle to bind to specific cell-surface markers.