BIND Therapeutics Co-Founders Demonstrate Ability to Cross Biological Barriers with Targeted Therapeutic Nanoparticles
Data Published in Science Translational Medicine Offer Potential New Applications for BIND’s Medicinal Nanoengineering Platform
BIND Therapeutics, Inc. (NASDAQ: BIND), a
In a paper entitled, “Transepithelial Transport of
“BIND has used its Medicinal Nanoengineering platform to produce a pipeline of Accurins, including its proprietary lead drug candidate, BIND-014, currently in Phase 2 clinical trials in
“Up to this point, biological barriers present in the human body, such as the intestinal epithelial lining, the blood brain barrier, and the mucosa of the lungs and eyes, have hindered absorption of nanoparticles. By targeting the neonatal Fc receptor, our founders have demonstrated the ability to successfully engineer targeted therapeutic nanoparticles that cross biological barriers and enter the bloodstream at therapeutic levels, which we believe could pave the road for opportunities for Accurin therapeutics for a myriad of other biological applications,” said Jeff Hrkach, Ph.D., BIND’s Senior Vice President of Technology, Research and Development.
BIND Therapeutics is a clinical-stage nanomedicine platform company developing Accurins, its novel targeted therapeutics. BIND intends to leverage its Medicinal Nanoengineering® platform to develop a pipeline of Accurins, initially in oncology, as well as Accurins in collaboration with biopharmaceutical companies. BIND’s lead drug candidate, BIND-014, is an Accurin that targets PSMA and contains docetaxel, a clinically-validated and widely used cancer chemotherapy drug. BIND-014 is currently in Phase 2 clinical trials for non-small cell lung cancer and metastatic castrate-resistant prostate cancer.
BIND has announced collaborations with Amgen Inc., Pfizer Inc. and AstraZeneca AB to develop Accurins based on therapeutic payloads from their product pipelines. BIND’s platform originated from the pioneering nanotechnology research at the Massachusetts Institute of Technology and Brigham and Women’s Hospital / Harvard Medical School of BIND’s scientific founders and directors Dr. Robert Langer and Dr. Omid Farokhzad.
For more information, please visit the company’s web site at www.bindtherapeutics.com