CML AT Medical and the Tomsk National Medical Center Have Developed Unique 3D Printed Cancer Implants

20 August 2020

The engineers of the CML AT Medical project company of the Northwest Technology Transfer Center (NTTC) together with Ph.D., Senior Research Fellow of the Oncology Research Institute of the Tomsk National Research Medical Center (TNRMC) of the Russian Academy of Sciences Ilya Anisenya have developed a number of unique bone implants designed for patients suffering from various forms of cancer. The NTTC is a part of the investment network of the RUSNANO’s Fund for Infrastructure and Educational Programs.

The customer was the Sintel manufacturing company, operating in reconstructive surgery. At the moment, the implants have been successfully installed in six patients of the Tomsk Scientific Research Center. The structures of titanium powder with a complex cellular structure have become a full-fledged replacement for the radius, humerus, tibia, and shoulder joint affected by cancerous tumors.

According to Yana Chekryzhova, Head of CML AT Medical, printed implants are often the only way to keep a person able to move and live a full life. Cancer patients need a strictly individual approach, taking into account the degree and form of bone damage, the location of the tumor, and many other important factors. 3D printing allows the manufacture of complex-shaped endoprostheses with a cellular surface structure that cannot be produced by traditional methods.

According to Ilya Anisenya, who carried out the surgeries, in all cases the implants were completely equivalent to the replacement bones of the patient, there were no problems when installing them, and the intervention itself was assessed as a successful one. Currently, implants show a good level of osteointegration, and patients undergo a post-surgery rehabilitation course. At CML AT Medical, the experience of cooperation is also positive and is planned to be developed. In September–October 2020, CML AT Medical intends to offer its products to a number of cancer centers across the country.

Additive technologies in medicine have started to be used relatively recently. The implant was first printed only in 2012 by the Belgian company LayerWise. At the same time, the first surgery was carried out to implant a 3D printed titanium lower jaw. Currently, more than 300,000 of such surgeries are performed in the United States every year. The Russian market for medical products using 3D printing technologies is only developing. Meanwhile, the CML AT Medical professionals have already managed to achieve the superiority of their implants over the available analogues on the market on a number of important parameters. Thus, due to the mesh structure of the product surface, designed by the company’s engineers, it was possible to provide better osteointegration of the implant into the patient’s bone tissue, which ensures the stability of the implant. In addition, the cost of CML AT Medical endoprosprothesses is on average 20% lower than the price of its competitors. The process of production of individual medical products from the moment of receiving CT images of the patient to the shipment of the finished product takes about 2.5 weeks, which is crucial for the surgical treatment of patients with severe forms of oncology.


The Fund for Infrastructure and Educational Programs was established in 2010 in accordance with Federal Law No. 211-FZ “On reorganization of the Russian Corporation of Nanotechnologies.” The Fund aims to develop the innovative infrastructure in the sphere of nanotechnology and implement the educational and infrastructure programs already started by RUSNANO.

The supreme collegial management body of the Fund is the Supervisory Board. Under the Fund’s Charter, the competence of the Supervisory Council, in particular, includes the issues of determining the priority directions of the Fund’s activity, as well as its strategy and budget. The Chairman of the Fund’s Executive Board, the collegial management body, is the Chairman of the Board of Management Company RUSNANO LLC Anatoly Chubais; the Chief Executive Officer of the Fund is Andrey Svinarenko.

* * *

CML AT Medical designs products at the interface of medical and engineering competences taking into account the requirements of the doctor and the specifics of production technologies. Its valuable asset is the development of individual endoprosthesis with improved osseointegration on the basis of patient’s Computed Tomography scans, fixing screws and plates for them, serial medical products and instruments. Thanks to the established partner network in 3D printing, machining, distribution and registration, the company is able to provide fast and efficient production of medical products from various materials.

For more information about the company, visit